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The school traces back to the College of Nursing, for which the Commission on Higher Education granted Saint Mary's a permit in June 1994. It became the College of Health Sciences in 2000, adding midwifery, medical laboratory science and pharmacy.
In school year 2016-2017 the Center for Natural Sciences merged with the School of Health Sciences to form the School of Health and Natural Sciences, which has since produced licensure examination topnotchers.
